Search results for "Macular dystrophy"
showing 2 items of 2 documents
The Role of Cadherins in Ca2+-Mediated Cell Adhesion and Inherited Photoreceptor Degeneration
2002
Cadherins are Ca2+-binding, transmembrane proteins involved in cell adhesion. Recently, three cadherin molecules, cadherin-23, protocadherin-15, and cadherin-3, were found to be defective in various human diseases, many of them with photoreceptor degeneration and/or sensorineural hearing loss as major features such Usher syndrome type 1D (USH1D), USH1F, and hypotrichosis with juvenile macular dystrophy. The process, by which mutations lead to photoreceptor degeneration is still not fully understood. Data from the inner ear phenotype of USH1 mouse models suggest that loss of cell adhesion is a crucial event.
Therapeutic use of human embryonic stem cells
2014
No Status Trial1 Not yet recruitingA Study Of Implantation Of Human Embryonic Stem Cell Derived Retinal Pig-ment Epithelium In Subjects With Acute Wet Age Related MacularDegeneration And Recent Rapid Vision Decline.2 RecruitingA Phase I/IIa, Open-Label, Single-Center, Prospective Study to Determine the Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (MA09-hRPE) Cells in Patients With Advanced Dry Age-related Macular Degeneration (AMD).3 RecruitingSafety and Tolerability of Sub-retinal Transplantation of Human Em-bryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt’s Macular…